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Inhibitory neurons which express vasoactive intestinal polypeptide, VIPs, are a small subset of the mammalian cortex but in importance live up to their acronym. New research shows that these critical control knobs of cortical activity are specifically activated by actions taken when rewards are anticipated rather than consummated. Main text
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Using cell-specific and genetically targeted approaches we have confirmed an indispensable role for vasoactive intestinal polypeptide-expressing SCN (SCN VIP) neurons, including their molecular.
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VIP gene transcripts are mainly found in neurons or neuron-related cells. VIP gene expression is regulated by neuronal and endocrine signals that contribute to its developmental control. VIP exerts its function via receptor-mediated systems, activating signal transduction pathways, including cAMP.
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This supports the idea that VIP cells contribute to the difference in coherence between matched and non-matched surrounds. Importantly, the regression slopes for coherence were significantly different from those for power (Figure 4 K, p = 0.004, n = 9, Wilcoxon signed rank test). Download : Download high-res image (827KB)
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Vasoactive intestinal peptide (VIP) is a neuropeptide belonging to the VIP/secretin/glucagon family of peptides that can be released from both neurons and immune cells. From: Brain, Behavior, and Immunity, 2009 About this page VIP Sandrine Passemard,. Vincent Lelièvre, in Handbook of Biologically Active Peptides (Second Edition), 2013
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VIP (Vasoactive Intestinal Peptide) is a Protein Coding gene. Diseases associated with VIP include Vipoma and Vasomotor Rhinitis.Among its related pathways are GPCR downstream signalling and Presynaptic function of Kainate receptors.Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity.
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Vip cells were activated when the mouse was whisking while they were inactive during non-whisking periods. Sst cells showed opposite firing patterns, being active during non-whisking while silent during whisking behavior, verifying previous findings [17].
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VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli | eLife Measurements of visual response to motion of different contrasts along with network modeling reveals a microcircuit in superficial layers of cortex that regulates the gain regime. Skip to Content eLife home page Menu
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of L2/3 VIP cells and L2/3 PYR cells during behavior in task-expert mice, as well as VIP cells in novice mice and in expert mice after Botox injection to induce whisker paralysis (mouse N's shown in Figure 1J). Whisker-evoked responses of VIP cells in S1 We performed 2-p imaging of L2/3 VIP interneurons in S1 during behavior in expert mice.
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Using multielectrode recording and optogenetic manipulations, we show that VIP neurons provide coordinated daily waves of GABAergic input to target cells across the paraventricular hypothalamus.
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A VIPoma is a neuroendocrine neoplasm secreting vasoactive intestinal peptide (VIP), usually presenting with severe watery secretory diarrhea, which can result in hypokalemia and metabolic acidosis and with flushes. Hypochlorhydria, stimulation of glycogenolysis, and hypercalcemia can be also found in VIPoma patients.
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Inhibitory Neurons: Vip Cells Hit the Brake on Inhibition Recent studies on vasoactive intestinal peptide-expressing inhibitory neurons in the barrel and auditory cortices of the mouse brain have shown that they form a disinhibitory circuitry that affects the excitability of pyramidal neurons. Carsten K. Pfeffer
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VIP cells, one of the major inhibitory cell types in neocortex 5, 6, are commonly found in superficial layers 7. They preferentially inhibit somatostatin positive (SST) cells that mediate.
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Vasoactive intestinal peptide (VIP) interneurons in sensory cortex modulate sensory responses based on global exploratory behavior and arousal state, but their function during non-exploratory, goal-directed behavior is not well understood.
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2200184 DOI: 10.1016/0165-6147(90)90253-5 Abstract VIP-containing cells in the neocortex are intrinsic neurons of the bipolar type, which release VIP through mechanisms that involve Ca2+ and lipoxygenase metabolites.
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Vasoactive intestinal peptide, also known as vasoactive intestinal polypeptide or VIP, is a peptide hormone that is vasoactive in the intestine. VIP is a peptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, the ligand of class II G protein-coupled receptors. [5]